Project leader for infection project. As project leader, identified a lead series from a virtual screen and delivered a candidate drug in less than 18 months. Two unique chemical series discovered and both led to candidate drugs for development. Lead chemist for infection project. Used fragment-based screening to identify a novel lead scaffold. The team identified multiple candidate drugs and two candidates reached the clinic. Managed multi-disciplinary lead optimization team responsible for delivery of candidate drug. Recommended advancement or termination of project to research management. Managed chemistry CROs and an internal chemistry group (7-10 FTEs) supporting project. Additional responsibilities included managing my own chemistry lab , goal setting and career growth/development for associate scientists. Experience in structure-based drug design, fragment and virtual screening for leads, novel drug delivery technology (nano-crystalline suspensions for IV & PO) and the use of computational models to predict properties of virtual compounds. Show less

* Team leader of lead generation group in infection department * Design and synthesis of antibacterial agents, structure-based design, antifungals. * Managed chemistry CRO supporting project and my own lab. * Generated two projects that advanced to lead identification.

* Design and synthesis of prodrugs for oncology candidate drug and kinase inhibitors. * Managed chemistry lab * Design and synthesis of VLA-4/VCAM antagonists. * Contributed intellectually to 3 patent applications. * Attended management courses on effective leadership. * Drew University course on medicinal chemistry

* Total synthesis of the naturally occurring antitumor metabolite, Calyculin A * Development of new synthetic methodology

Development of novel chemical derivatization methods for natural products, application of novel chemical derivatization methods for natural products on milligram to sub-milligram scale and developing new synthetic tools for preparing biochemical probes from natural products. Preparation of research reports and assisting with manuscripts, proposals, managing LINCHPIN activities and evaluation of new collaboration projects. Design of structural details regarding interactions with LINCHPIN collaborators such as collaboration models, proposal plan templates, service fee schedules and publication agreements.

Development of novel chemical derivatization methods for natural products, application of novel chemical derivatization methods for natural products on milligram to sub-milligram scale and developing new synthetic tools for preparing biochemical probes from natural products. Preparation of research reports and assisting with manuscripts, proposals, managing CPRIT lab activities and evaluation of new collaboration projects. Design of structural details regarding interactions with collaborators such as collaboration models, proposal plan templates, service fee schedules, IP and publication agreements. Optimization of chemical reactions using automation.