Developed models of neurotransmitter kinetics using dynamic PET. Designed MATLAB and C software programs for image analysis.

* Developed a new algorithm of SPECT reconstruction based on artificial neural * networks. * Worked on radiation transport modeling for nuclear emergency management. * Performed radiation monitoring duties.

* Directed PET and CT data acquisition for users of preclinical imaging services related * to neuroscience, diabetes and obesity, cardiovascular research, and others. * Planned and designed preclinical experiments, imaging protocols and workflows. * Studied the dopamine receptor system in the brain with dynamic PET. * Performed image processing, kinetic and statistical analysis for quantification of CNS * PET tracers, and evaluation of pharmacological and behavioral effects. * Wrote scientific papers and research grant applications. * Independently evaluated the performance of Inveon dedicated PET scanner. * Developed methods for in vivo dosimetry and biodistribution of new radiotracers in * mice and extrapolation to human. * Performed calibration and quality control for Inveon PET and CT scanners, and * Siemens HR+ clinical scanner. * Managed PET/CT imaging equipment, lab computer system, imaging data flow, * backup and recovery policies of imaging data.

* Analyzed spectroscopy data (Gammasphere experiment, Argonne National Lab) for the study neutron rich nuclei. Was teaching assistant for “Electricity and Magnetism”, and “Modern Physics Laboratory” courses.

* Lead molecular imaging studies to investigate human and animal disease, preventive methods, * and treatments * Conduct image-processing, analysis and modeling for existing or novel radiotracers, whole-body * biodistribution and dosimetry. * Research and assess new development in image processing or data modeling * Provide guidance on selection of radiotracers for further development and clinical study * Manage PET and SPECT acquisition protocols for pre-clinical and early clinical studies * Assess the acquisition and processing of image data in support of validation of quantitative * outcome measures * Install and evaluate available software packages for image processing * Develop needed software, methods and modeling when not already commercially available * Write publications and reports

* Molecular NeuroImaging provides neuroimaging research services to the pharmaceutical and biotech industries. By focusing on developing radioligands as tools for human research, we will improve early diagnosis and rapid drug development for neurodegenerative and neuropsychiatric disorders.MNI key activities: * Radioligand development * Early phase human drug-trials-displacement/occupancy * Large scale Phase II-IV clinical imaging trials. * Multi-center quantitative imaging trials - Clinical imaging site coordination as a technical CRO - Core image processing laboratory * Biomarker development – presymptomatic and disease progression.